Extracorporeal membrane oxygenation (ECMO) strategies during COVID are discussed in this spirited and fast-paced episode of the STS Webinar Series. J.W. Awori Hayanga, MD, MPH, and an esteemed panel consider sedation or cannulation when placing a COVID patient on ECMO. They do so while addressing lessons learned during the pandemic, amidst multiple COVID surges and evolving therapeutic modalities. Topics include: the relationship between patient selection and survivability, anticoagulation strategies in COVID patients, and the challenges of weaning patients off of sedation. Panelists include: Rakesh C. Arora, MD, PhD, who also serves as a digital moderator, Subhasis Chatterjee, MD, J.W. Awori Hayanga, MD, MPH, Bo Soo Kim, MD, Jonathan W. Haft, MD, HelenMari L. Merritt-Genore, DO, and Rita Karianna Milewski, MD, PhD, MSEd.