Cardiovascular disease is the #1 killer of people around the world, with approximately 18 million deaths annually, according to the World Health Organization. Treatment options for heart disease include lifestyle changes, stenting, and surgery. But which option is best and for which patients? Thomas E. MacGillivray, MD (Houston Methodist Hospital, Houston, TX), moderates a panel discussion with Jennifer S. Lawton, MD (Johns Hopkins Medicine, Baltimore, MD), John D. Puskas, MD (Mount Sinai Hospital, New York, NY), Marc Ruel, MD, MPH (University of Ottawa Heart Institute, Ottawa, Canada), and Joseph F. Sabik III, MD (University Hospitals, Cleveland, OH). They explore recent results from the ISCHEMIA trial, implications for the heart team, and which patients benefit the most from percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or medical therapy.